Protein nanotubes as state-of-the-art nanocarriers: Synthesis methods, simulation and applications

Application of food proteins as a tool to form nanostructures (especially nanotubular shapes) has been an interesting topic for both the food and pharmaceutical sectors. Organic and protein nanostructures have better biocompatibility and biodegradability compared to inorganic counterparts like carbon nanotubes; in addition, they can undergo surface modifications. Several organic nanotubes have been developed, meanwhile, the engineered protein nanotubes in the food science have been prepared from α-lactalbumin, ovalbumin, cyclic peptide nanotubes, collagen, bovine serum albumin, lysozyme and hydrophobins which are of great interest to be applied in the food industry considering their outstanding properties. This revision underlines the production of protein nanotubular structures and their applications as well as introducing the in silico studies which is a novel field in predicting the interactions of proteins with different molecules before running experimental tests and finally exploring the safety of protein nanotubes. Protein nanotubes have several advantages over other morphologies, such as the functionalizing ability of both the outer and inner layers, enabling an efficient delivery and controlled release and their ability as gelling agents. Also, regarding their natural source in foods, they are promising alternatives to carbon nanotubes.