血管周围上皮样细胞
病理
上皮样细胞
波形蛋白
荧光原位杂交
HMB-45型
肿瘤
生物
解剖(医学)
医学
免疫组织化学
解剖
基因
染色体
生物化学
作者
Jinghong Xu,Yu Yan,Xueping Xiang,Peter Jiang,Xiangrong Hu,Wenjun Yang
出处
期刊:American Journal of Clinical Pathology
[Oxford University Press]
日期:2019-05-29
卷期号:152 (2): 221-229
被引量:6
摘要
Abstract Objectives To review the clinicopathologic, immunophenotypic, and molecular features of gastric perivascular epithelioid cell tumor (PEComa). Methods We identified two new cases of gastric PEComa and summarized the clinical and pathologic characteristics of this rare neoplasm. Results The first case was a 48-year-old woman who was treated with an endoscopic submucosal dissection (ESD), and the second case was a 64-year-old man who received a distal gastrectomy. Microscopic examination showed one tumor was composed of purely epithelioid cells, while the other was composed of epithelioid and spindle cells. Both tumors were immunoreactive for melanocytic markers (HMB45 and Melan-A), smooth muscle actin, and vimentin. No TFE3 gene rearrangement was identified by fluorescence in situ hybridization in either case. Conclusions Gastric PEComa is an exceedingly rare neoplasm, with only seven other reported cases to date. We are the first to report the results of molecular assays for the TFE3 gene rearrangement associated with gastric PEComa.
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