异氰
化学
催化作用
氧化加成
噻唑烷
镍
配体(生物化学)
组合化学
氧化磷酸化
基质(水族馆)
原子经济
光化学
高分子化学
药物化学
有机化学
受体
地质学
海洋学
生物化学
作者
Wen‐Kui Yuan,Yan Fang Liu,Zhenggang Lan,Li‐Rong Wen,Ming Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2018-11-06
卷期号:20 (22): 7158-7162
被引量:29
标识
DOI:10.1021/acs.orglett.8b03098
摘要
An efficient synthesis of thiazolidine-2,4,5-triimine derivatives was developed via Ni-catalyzed oxidative double isocyanide insertion to thioureas under air conditions, in which thioureas play three roles as a substrate, a ligand, and overcoming isocyanide polymerization. The reaction is featured by employing a low-cost and low loading Ni(acac)2 catalyst, without any additives, and high atom economy. This is the first example to directly apply a Ni(II) catalyst in oxidative double isocyanide insertion reactions.
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