重新调整用途
癌症
嵌合抗原受体
肿瘤微环境
癌症研究
癌细胞
实体瘤
计算生物学
癌症治疗
转录组
肿瘤细胞
医学
计算机科学
生物
免疫疗法
内科学
生态学
作者
Sanna Madan,Alejandro Schäffer,Eytan Ruppin
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2022-06-15
卷期号:82 (12_Supplement): 2711-2711
标识
DOI:10.1158/1538-7445.am2022-2711
摘要
Abstract Chimeric antigen receptor (CAR) T cell therapy is a powerful and promising tool for unleashing lasting antitumor immunity, which is currently studied in numerous blood and solid cancers. Here, mining single cell transcriptomics datasets of solid tumors, we survey many existing CAR targets, aiming to identify new solid tumor types in which these targets are differentially expressed in tumor cells and not on non-tumor cells within the tumor microenvironment, thus providing new repurposing opportunities. Quite surprisingly, we find that many existing solid cancer CAR targets have a better discriminatory power in uncharted cancer types than in the ones they have been developed or being tested for. Furthermore, we show that several existing liquid cancer CAR targets may also hold promise in specific solid tumors. Taken together, this analysis uncovers a large potential of repurposing current CARs that is currently yet untapped. Citation Format: Sanna Madan, Alejandro Schäffer, Eytan Ruppin. Repurposing CAR targets in solid tumors from pan-cancer single-cell RNA-seq data [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2711.
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