脂肪组织
脂肪因子
心房颤动
内科学
促炎细胞因子
内分泌学
医学
肥胖
病理生理学
炎症
生物
胰岛素抵抗
作者
Monika Gawałko,Arnela Saljic,Na Li,Issam Abu-Taha,Thomas Jespersen,Dominik Linz,Stanley Nattel,Jordi Heijman,Anke C. Fender,Dobromir Dobrev
出处
期刊:Cardiovascular Research
[Oxford University Press]
日期:2022-06-11
卷期号:119 (3): 614-630
被引量:16
摘要
Obesity is an important contributing factor to the pathophysiology of atrial fibrillation (AF) and its complications by causing systemic changes, such as altered haemodynamic, increased sympathetic tone, and low-grade chronic inflammatory state. In addition, adipose tissue is a metabolically active organ that comprises various types of fat deposits with discrete composition and localization that show distinct functions. Fatty tissue differentially affects the evolution of AF, with highly secretory active visceral fat surrounding the heart generally having a more potent influence than the rather inert subcutaneous fat. A variety of proinflammatory, profibrotic, and vasoconstrictive mediators are secreted by adipose tissue, particularly originating from cardiac fat, that promote atrial remodelling and increase the susceptibility to AF. In this review, we address the role of obesity-related factors and in particular specific adipose tissue depots in driving AF risk. We discuss the distinct effects of key secreted adipokines from different adipose tissue depots and their participation in cardiac remodelling. The possible mechanistic basis and molecular determinants of adiposity-related AF are discussed, and finally, we highlight important gaps in current knowledge, areas requiring future investigation, and implications for clinical management.
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