化学
苯甲酸
尿素酶
活性化合物
阿切
克莱森缩合
酶
酪氨酸酶
戒指(化学)
活动站点
生物活性
立体化学
有机化学
乙酰胆碱酯酶
生物化学
催化作用
体外
作者
Bedriye Seda Kurşun Aktar,Yusuf Sıcak,Emine Elçin Oruç‐Emre
出处
期刊:International journal of chemistry and technology
[International Journal of Chemistry and Technology]
日期:2022-07-06
卷期号:6 (1): 7-14
被引量:2
标识
DOI:10.32571/ijct.1003871
摘要
A series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid. The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined. It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1. Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.
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