重编程
生物
表观遗传学
体细胞
染色质
后生
细胞命运测定
转录因子
转录组
计算生物学
细胞生物学
遗传学
DNA甲基化
细胞
基因
基因表达
作者
Chuan Chen,Yawei Gao,Wenqiang Liu,Shaorong Gao
标识
DOI:10.1093/biolre/ioac087
摘要
Abstract Epigenetic regulations play a central role in governing the embryo development and somatic cell reprogramming. Taking advantage of recent advances in low-input sequencing techniques, researchers have uncovered a comprehensive view of the epigenetic landscape during rapid transcriptome transitions involved in the cell fate commitment. The well-organized epigenetic reprogramming also highlights the essential roles of specific epigenetic regulators to support efficient regulation of transcription activity and chromatin remodeling. This review briefly introduces the recent progress in the molecular dynamics and regulation mechanisms implicated in mouse early embryo development and somatic cell reprograming, as well as the multi-omics regulatory mechanisms of totipotency mediated by several key factors, which provide valuable resources for further investigations on the complicated regulatory network in essential biological events.
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