成纤维细胞
生物
细胞外基质
纤维化
免疫疗法
内生
心脏纤维化
癌症研究
信使核糖核酸
免疫学
细胞
细胞生物学
作者
Ronald J. Vagnozzi,Timothy A. McKinsey
标识
DOI:10.1016/j.stem.2022.02.002
摘要
Fibrosis, or chronic fibroblast activation and extracellular matrix deposition, underlies most cardiovascular diseases and remains challenging to target therapeutically. Reported in Science by Rurik et al., modified mRNA technology can reprogram endogenous T cells into fibroblast-ablating CAR-Ts in mouse hearts, offering a promising and tractable immunotherapy approach for tackling fibrosis.
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