抗体
抗体-药物偶联物
结合
癌症研究
药品
医学
免疫检查点
免疫系统
免疫学
药理学
免疫疗法
单克隆抗体
数学分析
数学
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2016-02-01
卷期号:6 (2): OF3-OF3
被引量:3
标识
DOI:10.1158/2159-8290.cd-nb2015-172
摘要
The antibody-drug conjugate T-DM1 spurs immune cells to infiltrate HER2-positive breast tumors in patients. Treating mice that carry breast tumors with T-DM1 improves survival, but the tumors suppress the infiltrating lymphocytes. Combining T-DM1 with checkpoint inhibitors that block CTLA-4 and PD-1 overcomes this effect, eliminating breast tumors from 95% of the mice.
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