环氧化物
亲核细胞
苯胺
化学
产量(工程)
催化作用
胺气处理
酒
苯乙烯氧化物
组合化学
有机化学
戒指(化学)
氨基酸
布朗斯特德-洛瑞酸碱理论
氧化物
苯乙烯
药物化学
材料科学
聚合物
共聚物
冶金
生物化学
作者
Aparna Tyagi,Naveen Yadav,Jabir Khan,Samrat Mondal,Chinmoy Kumar Hazra
标识
DOI:10.1002/asia.202200379
摘要
A mild, efficient, and metal-free synthetic protocol for the synthesis of β-amino alcohols is reported. The reaction proceeds at room temperature with only 0.5 mol % catalyst loading and affords β-amino alcohol derivatives in excellent yield. This protocol is well-tolerated by a wide range of styrene oxide and aniline derivatives. A notably efficacious gram-scale synthesis is also reported with a high TON=842. Further, the Hammett correlation study was also performed to identify the rate-determining step.
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