比格里坎
卢米坎
弹性蛋白
多糖
细胞外基质
主动脉
蛋白多糖
胸主动脉
解剖
维斯坎
细胞生物学
病理
生物
医学
化学
作者
Josephina Meester,Pauline De Kinderen,Aline Verstraeten,Bart Loeys
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2022-06-01
卷期号:322 (6): C1214-C1222
被引量:2
标识
DOI:10.1152/ajpcell.00036.2022
摘要
The class I small leucine-rich proteoglycan biglycan is a crucial structural extracellular matrix component that interacts with a wide range of extracellular matrix molecules. In addition, biglycan is involved in sequestering growth factors such as transforming growth factor-β and bone morphogenetic proteins and thereby regulating pathway activity. Biglycan consists of a 42-kDa core protein linked to two glycosaminoglycan side chains and both are involved in protein interactions. Biglycan is encoded by the BGN gene located on the X-chromosome and is expressed in various tissues, including vascular tissue, skin, brain, kidney, lung, the immune system, and the musculoskeletal system. Although an increasing amount of data on the biological function of biglycan in the vasculature has been produced, its role in thoracic aortic aneurysms is still not fully elucidated. This review focuses on the role of biglycan in the healthy thoracic aorta and the development of thoracic aortic aneurysm and dissections in both mice and humans.
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