血栓
微塑料
纤维蛋白
血栓形成
体外
血小板
血流
毒性
医学
生物医学工程
药理学
化学
心脏病学
内科学
免疫学
生物化学
环境化学
作者
Longfei Chen,Y. Zheng,Yantong Liu,Pengfu Tian,Le Yu,Long Bai,Fuling Zhou,Yi Yang,Yanxiang Cheng,Xinghuan Wang,Lirong Zheng,Fenghua Jiang,Yimin Zhu
出处
期刊:Lab on a Chip
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:22 (7): 1344-1353
被引量:23
摘要
The potential impact of microplastics (MPs) on health has caused great concern, and a toxicology platform that realistically reproduces the system behaviour is urgently needed to further explore and validate MP-related health issues. Herein, we introduce an optically assisted thrombus platform to reveal the interaction of MPs with the vascular system. The risk of accumulation has also been evaluated using a mouse model, and the effect of MPs on the properties of the thrombus are validated via in vitro experiments. The microfluidic system is endothelialized, and the regional tissue injury-induced thrombosis is then realized through optical irradiation. Whole blood is perfused with MPs, and the invasion process visualized and recorded. The mouse model shows a cumulative risk in the blood with continuous exposure to MPs (P-value < 0.0001). The on-chip results show that MP invasion leads to decreased binding of fibrin to platelets (P-value < 0.0001), which is consistent with the results of the in vitro experiments, and shows a high risk of thrombus shedding in real blood flow compared with normal thrombus. This work provides a new method to further reveal MP-related health risks.
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