萧条(经济学)
医学
小胶质细胞
冲程(发动机)
缺血
纹状体
内科学
心脏病学
炎症
机械工程
工程类
宏观经济学
经济
多巴胺
作者
Tao Xi,Si-Pei Wu,Wenjing Tang,Li Lu,Lijun Huang,Danheng Mo,Chujuan Liu,Tao Song,Shuling Wang,Wei Hua Jia,Jun He
出处
期刊:Brain Injury
[Informa]
日期:2022-01-02
卷期号:36 (1): 127-136
被引量:3
标识
DOI:10.1080/02699052.2022.2034949
摘要
Poststroke depression (PSD) is a common complication that seriously affects the functional recovery and prognosis of an individual. As some patients with PSD fail to respond to drug therapy, it is urgent to find a viable alternative treatment.An active exercise program known as foraging exercise (FE), using food as bait, was designed. First, focal ischemia and chronic unpredictable mild stress (CUMS) were used to establish a PSD model in rats. FE was then performed for 4 weeks. Body weight and behavioral assessments were conducted at the end of the 4th and 8th weeks.After 8 weeks, the results revealed that, compared with the PSD group, the behavioral scores of the rats in the PSD/FE group were significantly improved, the expression of Iba-1 in the affected frontal lobe and striatum was decreased, and serum levels of IL-6 and the IL-6/IL-10 ratio were downregulated. However, the ratio of residual brain volume in rats that had experienced CUMS was significantly less than that in the stroke group.FE can alleviate the behavioral scores of PSD rats, and its mechanism may be related to a modulation of the immune-inflammation response of microglia. Furthermore, chronic, persistent stress may increase the volume of cerebral infarction after stroke.
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