生物
有机体
电池类型
功能(生物学)
分类
计算生物学
细胞
概念框架
认知科学
神经科学
进化生物学
遗传学
认识论
计算机科学
人工智能
心理学
哲学
出处
期刊:Cell
[Elsevier]
日期:2022-07-01
卷期号:185 (15): 2739-2755
被引量:63
标识
DOI:10.1016/j.cell.2022.06.031
摘要
Summary
Cell types are the basic functional units of an organism. Cell types exhibit diverse phenotypic properties at multiple levels, making them challenging to define, categorize, and understand. This review provides an overview of the basic principles of cell types rooted in evolution and development and discusses approaches to characterize and classify cell types and investigate how they contribute to the organism's function, using the mammalian brain as a primary example. I propose a roadmap toward a conceptual framework and knowledge base of cell types that will enable a deeper understanding of the dynamic changes of cellular function under healthy and diseased conditions.
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