This paper examined the interrelation between social support and coping in a longitudinal study of 380 clinically depressed individuals. A two-wave, two-variable panel analysis revealed that connections between support and coping varied by gender and across the specific sources of support and modes of coping examined. In the family context, increases in support were related to increases in problem-solving coping among women and to a decline in emotional discharge coping among men. In the work context, increases in social support were related to a greater reliance on affective regulation among women and to more information/support seeking among men. Overall, the results suggest that specific aspects of support and coping processes jointly mediate the link between stress and adjustment among depressed individuals.