神经传递
神经科学
癫痫
作用机理
药理学
兴奋性突触后电位
抑制性突触后电位
抗癫痫药
神经递质
动作(物理)
离子通道
神经递质药
医学
生物
受体
中枢神经系统
内科学
物理
生物化学
体外
量子力学
作者
Patrick Kwan,Graeme J. Sills,Martin J. Brodie
标识
DOI:10.1016/s0163-7258(01)00122-x
摘要
In the past decade, nine new drugs have been licensed for the treatment of epilepsy. With limited clinical experience of these agents, the mechanisms of action of antiepileptic drugs may be an important criterion in the selection of the most suitable treatment regimens for individual patients. At the cellular level, three basic mechanisms are recognised: modulation of voltage-dependent ion channels, enhancement of inhibitory neurotransmission, and attenuation of excitatory transmission. In this review, we will attempt to introduce the concepts of ion channel and neurotransmitter modulation and, thereafter, group currently used antiepileptic drugs according to their principal mechanisms of action.
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