氰化
铋
三甲硅基氰化物
催化作用
化学
氰化物
醛
有机化学
组合化学
作者
Makoto Wada,Tomohiro Takahashi,Terutomo Domae,Tomohiro Fukuma,Norikazu Miyoshi,Keith Smith
标识
DOI:10.1016/s0957-4166(97)00570-3
摘要
Bismuth(III) chloride (BiCl3) was found to work efficiently as a versatile catalyst for cyanation of aldehydes with trimethylsilyl cyanide to afford the corresponding cyanohydrins in high yields. Triphenylbismuthan (Ph3Bi) is also effective. The reaction has been applied to the asymmetric cyanation of a variety of aldehydes in high yields with moderate to good enantioselectivities by use of a chiral bismuth catalyst prepared in situ from BiCl3 and (2R,3R)-(+)-diethyl tartrate.
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