医学
哮喘
转化生长因子
免疫学
背景(考古学)
调解人
气道阻塞
气道
表型
促炎细胞因子
炎症
疾病
细胞激素风暴
基因
病理
内科学
生物
传染病(医学专业)
遗传学
2019年冠状病毒病(COVID-19)
古生物学
外科
作者
Mazen Al‐Alawi,Tidi Hassan,Sanjay H. Chotirmall
标识
DOI:10.1016/j.rmed.2014.08.008
摘要
Asthma is a chronic inflammatory airway disease involving complex interplay between resident and infiltrative cells, which in turn are regulated by a wide range of host mediators. Identifying useful biomarkers correlating with clinical symptoms and degree of airway obstruction remain important to effective future asthma treatments. Transforming growth factor β (TGF-β) is a major mediator involved in pro-inflammatory responses and fibrotic tissue remodeling within the asthmatic lung. Its role however, as a therapeutic target remains controversial. The aim of this review is to highlight its role in severe asthma including interactions with adaptive T-helper cells, cytokines and differentiation through regulatory T-cells. Associations between TGF-β and eosinophils will be addressed and the effects of genetic polymorphisms of the TGF-β1 gene explored in the context of asthma. We highlight TGF-β1 as a potential future therapeutic target in severe asthma including its importance in identifying emerging clinical phenotypes in asthmatic subjects who may be suitable for individualized therapy through TGF-β modulation.
科研通智能强力驱动
Strongly Powered by AbleSci AI