化学
戒指(化学)
酰胺
脚手架
组合化学
炔烃
席夫碱
亚胺
缩合反应
级联反应
发散合成
偶联反应
立体化学
药物化学
有机化学
催化作用
生物医学工程
医学
作者
Rosliana Halim,Luigi Aurelio,Peter J. Scammells,Bernard L. Flynn
摘要
N-(2-Iodophenyl)imines A are readily formed from Schiff’s base condensation of 2-iodoanilines with carbonyls and ketals. These imines provide useful substrates in scaffold-divergent synthesis through the attachment of an alkyne (Songashira coupling or acyl substitution of a Weinreb amide) followed by an iodonium-induced reaction cascade to give ring-fused indoles B, quinolines C, or quinolones D depending on the reaction conditions employed.
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