核糖体生物发生
生物发生
核糖体蛋白
核糖体
细胞生物学
磷酸化
生物
核仁
终端(电信)
体外
生物化学
细胞质
核糖核酸
基因
计算机科学
电信
作者
Barbara Michalec-Wawiórka,Leszek Wawiórka,Kamil Deryło,Dawid Krokowski,Aleksandra Boguszewska,Eliza Molestak,Monika Szajwaj,Marek Tchórzewski
标识
DOI:10.1016/j.biocel.2015.10.018
摘要
Protein Mrt4 is one of trans-acting factors involved in ribosome biogenesis, which in higher eukaryotic cells contains a C-terminal extension similar to the C-terminal part of ribosomal P proteins. We show that human Mrt4 (hMrt4/MRTO4) undergoes phosphorylation in vivo and that serines S229, S233, and S235, placed within its acidic C-termini, have been phosphorylated by CK2 kinase in vitro. Such modification does not alter the subcellular distribution of hMrt4 in standard conditions but affects its molecular behavior during ActD induced nucleolar stress. Thus, we propose a new regulatory element important for the stress response pathway connecting ribosome biogenesis with cellular metabolism.
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