蛋白酵素
病理生理学
病理
生物
程序性细胞死亡
纤维帽
蛋白酶
细胞
医学
细胞生物学
癌症研究
细胞凋亡
酶
遗传学
生物化学
作者
Carlos Silvestre-Roig,Menno P.J. de Winther,Christian Weber,Mat J.A.P. Daemen,Esther Lutgens,Oliver Soehnlein
出处
期刊:Circulation Research
[Ovid Technologies (Wolters Kluwer)]
日期:2014-01-03
卷期号:114 (1): 214-226
被引量:266
标识
DOI:10.1161/circresaha.114.302355
摘要
Understanding the pathophysiology of atherogenesis and the progression of atherosclerosis have been major goals of cardiovascular research during the previous decades. However, the complex molecular and cellular mechanisms underlying plaque destabilization remain largely obscure. Here, we review how lesional cells undergo cell death and how failed clearance exacerbates necrotic core formation. Advanced atherosclerotic lesions are further weakened by the pronounced local activity of matrix-degrading proteases as well as immature neovessels sprouting into the lesion. To stimulate translation of the current knowledge of molecular mechanisms of plaque destabilization into clinical studies, we further summarize available animal models of plaque destabilization. Based on the molecular mechanisms leading to plaque instability, we outline the current status of clinical and preclinical trials to induce plaque stability with a focus on induction of dead cell clearance, inhibition of protease activity, and dampening of inflammatory cell recruitment.
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