疏水效应
吸附
化学
水溶液
基质(化学分析)
共价键
烷基
化学工程
溶剂
脂质A
复合数
有机化学
高分子化学
脂多糖
色谱法
材料科学
复合材料
内分泌学
工程类
医学
作者
Kenneth C. Hou,Richard P. Zaniewski
标识
DOI:10.1016/0304-4165(91)90195-m
摘要
Endotoxin, a major pyrogen of concern to the biological industry, is a lipopolysaccharide containing a highly hydrophobic region, lipid A, in its structure. The effect of hydrophobic interaction on endotoxin adsorption from an aqueous solution was studied by covalently bonding aminoalkyl groups with varying hydrocarbon lengths to a cellulose and acrylic composite matrix. The amount of endotoxin adsorbed on the matrix increased with the increasing length of alkyl groups, demonstrating the contribution of hydrophobic interaction between endotoxin and the solid matrix. Both the hydrophobic and the charge interaction prove to be effective for endotoxin adsorption, and a synergistic effect from the dual chemical forces is achievable under specified conditions. The effect of solvent, pH and salts on endotoxin adsorption provides further evidence for the importance of hydrophobic force as a means of removing endotoxin from aqueous solutions.
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