Influence of PPAR Dual Agonists and Cardiovascular Complications

Cardiovascular disorders are the major cause of mortality in patients of diabetes mellitus.Peroxisome proliferator activated receptors(PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily comprising three subtypes: PPAR-α,PPAR-δ and PPAR-γ.The PPARα/γ dual agonists were developed to increase insulin sensitivity and simultaneously prevent diabetic cardiovascular complications.Further studies are on track to develop PPARα/δ and PPAR/γ dual agonists and PPARα/δ/γ pan agonists for the treatment of diabetic cardiovascular complications.This review analyzes the protective and detrimental effect of PPAR agonists in diabetic cardiovascular complications.