Effect of tirofiban on TIMI flow in patients with STEMI during primary PCI

Objective To eveluate the effect of tirofiban on TIMI flow in patients with STEMI during primary PCI. Methods Forty-eight patients with STEMI who underwent primary PCI were randomly divided into two groups which were: the tirofiban+PCI group (n=27) and the primary PCI group (n=21). The TIMI flow before and after the operation were reviewed angiographically. Results A greater percentage of TIMI 1 flow was archieved in the triofiban+PCI group compared with the primary PCI group before operation (37% vs 9.5%, P0.05). On the other hand, TIMI 0 flow was more commonly found in patients in the primary PCI group compared with the tirofiban+PCI group (38.1% vs 7.4%, P0.01). There was no difference in the archievement of TIMI 3 flow between the two groups after operation, but the occurance of TIMI 2 flow was less in the tirofiban+PCI group compared with the primary PCI group. Conclusion Tirofiban may improve TIMI flow of the IRA in patients with STEMI during primary PCI.