Objective To observe and evaluate the treatment effect of lipoic acid combined with Kudiezi injection on diabetic peripheral neuropathy. Methods 60 diabetic peripheral neuropathy patients w ere randomly divided into observation group and control group. Observation group w as given Kudiezi injection 40 mL,and lipoic acid 60 mL for 14 days; control group w as given lipoic acid 60 mL for 14 days. The nerve conduction velocity,sensory symptoms and total therapeutic effect of the tw o groups w ere compared before and after treatment. Results After treatment,sensory symptoms and nerve conduction velocity of the tw o groups w ere all improved compared w ith before treatment( P 0. 05). The efficiency of observation group w as better than that of control group( P 0. 05). Conclusion The effect of lipoic acid combined w ith Kudiezi injection for diabetic peripheral neuropathy is ideal.