The value of the contents of serum HIF-1α and Her-2 detected by suspension array in the diagnosis of breast cancer

Objective To explore the expression of hypoxia induced factor 1α(HIF-1α) and Her-2 in the serum of breast cancer,and the relationship between the two as well as its value in clinical diagnose of breast cancer.Method Suspension array was used to test the content of serum HIF-1α and Her-2 in 117 cases of original breast can-cer,10 cases of recurrent breast cancer,20 cases of benign breast tumor and 31 healthy people.Result The expressions of serum HIF-1α and Her-2 in original and recurrent breast cancer are obviously higher than benign tumor and healthy people(P 0.01).Recurrent breast cancer is significantly higher than original ones(P 0.05).No statistically differences in either HIF-1α or Her-2 were found between benign tumor and healthy people(P 0.05).The expression of serum HIF-1α and Her-2 goes up with the increasing rate of the different stages of breast cancer,histological grade,the size of tumor.It increases with lymph node metastasis(P 0.01) with some gaps in statistics within the group(P 0.05).The positive correlation between the expression of HIF-1α and Her-2 was observed in the patients of breast cancer(P = 0.00).Conclusion Serum HIF-1α and Her-2 may accurately reflect the biological characteristics of breast cancer and play an important role in evaluating prognosis.