Acute Toxicity of Monacetin, Diacetin and Triacetin

A study of the toxicity of the acetins reveals that the subcutaneous LD50 for monacetin is approximately 5.5 cc per kilo for inbred albino rats, and 3.5 cc per kilo for inbred white mice. The LD50 dose for diacetin is 4.0 cc and 2.5 cc per kilo, respectively, and for triacetin 2.8 cc and 2.3 cc per kilo, respectively. Slight irritation to mucous membranes and occasionally to cutaneous tissues was noted with monacetin. Monacetin did not hemolize blood corpuscles in dilutions of 1:500 or greater. Blood serum and monacetin are compatible with a resulting pH of 7.45. Diacetin and triacetin are more irritating to tissues, are slightly hemolytic and are relatively incompatible with blood serum.