Regulating Effect of Modified Yinchen Wuling Powder on Xanthine Oxidase Activity in Rats with Hyperuricemia

Objective To investigate the effect of modified Yinchen Wuling Powder on the levels of serum uric acid and xanthine oxidase in rats with hyperuricemia,and explore its mechanism.Methods Rat models of hyperuricemia were induced by intragastric administration of adenine and ethambutol hydrochloride,then treated with different dose of modified Yinchen Wuling Powder,allopurinol respectively.The levels of serum uric acid and xanthine oxidase were detected at 7th,14th and 21th day after the experiment.Results The level of serum uric acid in rats with hyperuricemia was decreased obviously in modified Yinchen Wuling Powder groups with middle and high dose(P0.05),and the level of xanthine oxidase was decreased obviously in modified Yinchen Wuling Powder group with middle dose(P0.05).Conclusion Modified Yinchen Wuling Powder has a role of prevention and treament on hyperuricemia.