Statins has accumulated a large number of consistent clinical research evidence in the prevention of atherosclerosis and improving the prognosis.Most statins were well tolerated overall,but the understanding of the adverse effects of statins has also gone through a gradual process of change.The concerns and controversy about statin muscle toxicity,liver damage,nervous system adverse reactions,new tumors and diabetes has not stopped in recent years.Therefore the adverse effects of statins and its related factors in progress is reviewed in this article.