Current Perspectives on Pyrazole Scaffolds and Their Potential Impact on Alzheimer's Disease

Alzheimer's disease (AD) is aserious problem among the elderly, with symptoms including dementia, memory loss, and behavioral changes caused by cholinergic neuron decline and other triggers. The search for novel and potential medications is ongoing, as noncurable treatments are presently the sole choice to deal with AD. Heterocyclic compounds, notably pyrazole, have emerged as pivotal in new drug development endeavors. Over the past decade, pyrazole has gained attention as a promising scaffold for anti-AD therapeutics, demonstrating efficacy over 37 crucial AD targets, including AChE, BuChE, BACE1, β-amyloid, MAO, and COX-1/2. The STRING-based approach is discussed to prioritize complex targets. The VOSviewer network is analyzed to demonstrate the correlation between different targets, AD, and pyrazole scaffolds. This chapter focuses on the target prioritizing approach and the significance of pyrazole scaffolds and their derivatives in AD therapy. The structural features and SAR of pyrazole from the previous ten years of study are also discussed. We believe that advances in pyrazole research will give rise to a promising future for novel treatment management strategies for Alzheimer's disease.