Understanding stress‐induced transmission of peripherally derived factors into the brain and responses in non‐neuronal cells

Abstract Stress is a significant cause of mental disorders, for which effective treatments remain limited due to an insufficient understanding of its pathogenic mechanisms. Recent research has increasingly focused on non‐neuronal cells to elucidate the molecular mechanisms underlying psychopathology. In this review, we summarize the current knowledge on how non‐neuronal cells in the central nervous system, including microglia, astrocytes, and oligodendrocytes, respond to peripherally derived stress‐related factors and how these responses contribute to the development of mental disorders. A more comprehensive understanding of stress‐induced alterations, with careful consideration of the type and timing of stress exposure, will provide fundamental insights into the pathogenesis of diverse stress‐related mental disorders. image