Osteoarthritis year in review 2024: Genetics, genomics, and epigenetics

OBJECTIVE: The purpose of this narrative review is to highlight the advances made in the past 12 months in the field of osteoarthritis genetics, genomics and epigenetics. METHODS: The Medline and Embase databases were systematically searched for original publications using terminology, and combinations of terminology, relating to: "osteoarthritis", "genetics", "genomics", and "epigenetics". Only original research articles published in the English language between the OARSI congresses of April 2032 and April 2024 were considered. RESULTS: This narrative review focuses only on studies using genome-wide omics techniques in human material. There was a rise in functional genomics studies across different osteoarthritis-relevant tissues, which have robustly identified an additional 26 genes involved in osteoarthritis pathology. Two of such previously identified genes (MGP, ALDH1A2) are currently the target of ongoing clinical trials for osteoarthritis. This past year also saw the use of single-cell transcriptomics and two relatively new omics: epitranscriptomics and mitochondrial genomics. CONCLUSION: This past year of genomics research has led to multiple exciting findings involving genes and mechanisms linked to osteoarthritis. Moreover, the comprehensive genome-wide omics datasets generated for diverse osteoarthritis tissues will prove invaluable for future research aimed at elucidating more causal biological mechanisms and possible therapeutic targets for osteoarthritis.