某种肠道细菌
谷氨酸棒杆菌
丁酸盐
肠道菌群
生物
细菌
微生物学
微生物群
2型糖尿病
生物化学
生物信息学
糖尿病
遗传学
内分泌学
发酵
作者
Jianming Ye,Yihua Li,Xiaochen Wang,Yu Meng,Xuehua Liu,H Zhang,Qingguo Meng,Usman Majeed,Li-juan Jian,Wei Song,Xue Wang,Yongsheng Luo,Tianli Yue
标识
DOI:10.1016/j.foodres.2023.113163
摘要
Accumulating evidences strongly support the correlations between the compositions of gut microbiome and therapeutic effects on Type 2 diabetes (T2D). Notably, gut microbes such as Akkermansia muciniphila are found able to regulate microecological balance and alleviate dysmetabolism of mice bearing T2D. In order to search out similarly functional bacteria, bacteriophage MS2 with a good specificity to bacteria carrying fertility (F) factor were used to treat T2D mice. Based on multi-omics analysis of microbiome and global metabolism of mice, we observed that gavage of bacteriophage MS2 and metformin led to a significant increase in the abundance of Corynebacterium glutamicum and A. muciniphila, respectively. Consequently, the gut microbiota were remodeled, leading to variations in metabolites and a substantial increase in short-chain fatty acids (SCFAs). In which, the amount of acetate, propionate, and butyrate presented negative correlations to that of proinflammatory cytokines, which was beneficial to repairing the intestinal barriers and improving their functions. Moreover, main short fatty acid (SCFA) producers exhibited positive interactions, further facilitating the restoration of gut eubiosis. These findings revealed that C. glutamicum and its metabolites may be potential dietary supplements for the treatment of T2D. Moreover, our research contributes to a novel understanding of the underlying mechanism by which functional foods exert their anti-diabetic effects.
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