聚乳酸
伤口愈合
血小板
血小板活化
炎症
富血小板血浆
血小板因子4
巨噬细胞极化
化学
细胞生物学
免疫学
医学
巨噬细胞
生物化学
生物
体外
有机化学
聚合物
作者
Tianci Zhang,Zehong Xiang,Lei Liu,Zhanhong Ma,Mikhail A. Panteleev,Fazly I. Ataullakhanov,Qiang Shi
标识
DOI:10.1002/mabi.202300036
摘要
Tight manipulation of the initial leukocytes infiltration and macrophages plasticity toward the M2 phenotype remain a challenge for diabetic wound healing. Inspired by the platelet function and platelet-macrophage interaction, a platelet-anchored polylactic acid-b-polyethylene glycol-b-polylactic acid (PLA-PEG-PLA) electrospun dressing is developed for inflammatory modulation and diabetic wounds healing acceleration. PLA-PEG-PLA electrospun meshes encapsulated with thymosin β4 (Tβ4) and CaCl2 is fabricated with electrospinning, followed by immersion of electrospun mesh in platelet-rich plasma to firmly anchor the platelets. It is demonstrated that the anchored platelets on electrospun mesh can enhance the initial macrophage recruitment and control the Tβ4 release from electrospun meshes to facilitate the macrophages polarization to the M2 phenotype. The inflammatory regulation promotes the expression of vascular endothelial growth factor and the migration of vascular endothelial cells for angiogenesis, resulting in accelerated diabetic wounds healing. Therefore, this work paved a new way to design platelet-inspired electrospun meshes for inflammation manipulation and diabetic wound healing.
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