胶粘剂
壳聚糖
止血
复合数
粘附
凝结
材料科学
组织粘连
石墨烯
海绵
生物医学工程
复合材料
化学
纳米技术
外科
图层(电子)
医学
精神科
生物
植物
生物化学
作者
Fanglin Du,A Wenjing,Fang Liu,Bingxin Wu,Yichun Liu,Weitao Zheng,Wenli Feng,Guofeng Li,Xing Wang
标识
DOI:10.1016/j.carbpol.2023.121058
摘要
Hydrophilic hemostatic sponge plays an important role in trauma bleeding control because of its robust coagulant functions. However, its strong tissue adhesion can easily result in wound tear and rebleeding during removing the sponge. Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported. For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models. For another, CSAG shows low tissue adhesion; its peeling force is approximately 79.3 % lower than the commercial gauze. Moreover, in the peeling process, CSAG triggers partial detachment of the blood scab, because of the exist of bubbles or cavities at the interface, allowing the CSAG to be easily and safely peeled off from the wound without rebleeding. This study opens new avenues in constructing anti-adhesive trauma hemostatic materials.
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