Glutathione-ascorbic acid-functionalized molybdenum oxide quantum dots-based fluorescent sensor for the detection of isoniazid drug in pharmaceutical samples

Herein, glutathione-ascorbic acid-functionalized molybdenum oxide quantum dots (GSH-AA-MoOx QDs) are synthesized by the conventional method and used as a fluorescent probe for the rapid detection of isoniazid drug in pharmaceutical samples. Ascorbic acid and glutathione are used as surface ligands for the modification of MoOx QDs. The as-synthesized GSH-AA-MoOx QDs display λEm at 416 nm when applied λEx at 330 nm. The introduction of isoniazid drug into GSH-AA-MoOx QDs solution results the assembly of GSH-AA-MoOx QDs-isoniazid nanoarchitectures, leading to quench λEm at 416 nm. Thus, GSH-AA-MoOx QDs can work as a fluorescent sensor for the rapid identification of isoniazid in real samples. The as-prepared GSH-AA-MoOx QDs not only allows superior analytical features (rapidity, and selectivity) toward isoniazid with the detection limit of 94 nM, but also displays fluorescence "turn-off" response for assaying of isoniazid in real samples (pharmaceutical and biofluids). Finally, GSH-AA-MoOx QDs are highly promising fluorescent probe for the rapid detection of isoniazid in real samples.