Antimicrobial and anti-acetylcholinesterase activities of secondary metabolites isolated from Aspergillus fumigatus MNY-14

A systematic investigation of the secondary metabolites of Aspergillus fumigatus MNY-14, which was isolated from the ripe leaves of Achyranthes longifolia, led to the isolation of eighteen compounds, including twelve indole diketopiperazine alkaloids (1-12), an α-pyrone meroterpenoid (13), a nortriterpenoid (14), two benzophenones (15-16), and two quinoline alkaloids (17-18). Among them, compounds 8, 17 and 18 were isolated for the first time from A. fumigatus. The chemotaxonomic significance of the secondary metabolites was discussed. Some of the isolates (6, 10, 11, 10, 15 and 16) could be used as chemical markers for strain identification of this fungus. In addition, some of the isolates showed certain antimicrobial and acetylcholinesterase inhibitory activities.