吉西他滨
胰腺导管腺癌
医学
腺癌
免疫组织化学
内科学
化疗
内镜超声
优势比
胰腺癌
肿瘤科
胃肠病学
病理
癌症
放射科
作者
Ko Tomishima,Toshio Fujisawa,Yuki Fukumura,Mako Ushio,Taito Fukuma,Sho Takahashi,Yusuke Takasaki,Akira Suzuki,Koichi Ito,Shōzō Ishii,Takashi Yao,Akihito Nagahara,Hiroyuki Isayama
出处
期刊:Pancreas
[Ovid Technologies (Wolters Kluwer)]
日期:2022-10-01
卷期号:51 (9): 1133-1139
标识
DOI:10.1097/mpa.0000000000002151
摘要
Pancreatic ductal adenocarcinoma with strong expression of interleukin-13 receptor α2 (IL-13Rα2) was associated with poor prognosis and gemcitabine resistance in an orthotopic mouse model. We evaluated the influence of IL-13Rα2 expression in the endoscopic ultrasound-fine needle aspiration (EUS-FNA) specimen.We included patients with pancreatic ductal adenocarcinoma, as diagnosed by EUS-FNA, who received gemcitabine-based chemotherapy (G-CTX). Tumor expression of IL-13Rα2 was assessed by immunohistochemistry and classified using a three scale (negative, weak, or strong) in a blinded fashion. The effect of G-CTX was assessed by tumor reduction rate by computed tomography after 3 months.A total of 95 patients were enrolled, and 63 and 32 cases were determined with strong and weak/negative expression of IL-13Rα2. The IL-13Rα2-strong group showed significantly poorer progression-free and overall survival rates than weak/negative group (P = 0.0191 and P = 0.0062, respectively). Strong expression of IL-13Rα2 was associated with progression factor after 3 months of the first G-CTX (odds ratio, 13.72; P = 0.0143).Pancreatic ductal adenocarcinoma with strong expression of IL-13Rα2 in EUS-FNA specimens showed poor prognosis and poor response to G-CTX.
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