Antimicrobial poly(aspartic acid) based self-healing hydrogel with enhance cell migration rate for burn wound treatment

Bacterial infection of the trauma can cause the wound decay to slow down the healing process and worsen the patient's condition. Recently, the treatment of infected wounds with hydrogels has received great attentions in the development of wound dressings. In this research, the poly (aspartic acid) (PAsp) with hydrazide functional groups (PAH) was hydrazinolyzed from poly (succinimide) (PSI) and cross-linked with dialdehyde functionalized PEO to prepare self-healing hydrogels for bacterial infection prone burn wound treatment. In addition, the antibacterial quaternary ammonium moiety and the aniline tetramer (AT) were imported to the PAH to enhance the antibacterial property and reactive oxygen species (ROS) scavenging activity of the hydrogel to accelerate burn wound repairing rate. The functionalized hydrogel showed expected antibacterial property with good biocompatibility well preserved. The in vivo burn wound repairing experiment indicated this antibacterial hydrogel enhance the burn wound repairing performance and could be used as infectious wound dressing.