已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Genetically Proxied Sarcopenia-Related Muscle Traits and Depression: Evidence from the FinnGen Cohort

肌萎缩 萧条(经济学) 医学 优势比 孟德尔随机化 内科学 置信区间 队列 瘦体质量 物理疗法 生物 遗传学 体重 遗传变异 基因 基因型 经济 宏观经济学
作者
Zheng‐tao Lv,Yingchao Zhao,Jiarui Cui,Jiaming Zhang
出处
期刊:American Journal of Geriatric Psychiatry [Elsevier]
卷期号:32 (1): 32-41 被引量:1
标识
DOI:10.1016/j.jagp.2023.08.001
摘要

Sarcopenia and depression are common and often coexist in the elderly. This study aims to determine the impact of sarcopenia-related muscle traits on depression.A two-sample Mendelian randomization (MR) study was performed on the summary-level data from the FinnGen cohort to estimate the causal association of appendicular lean mass (ALM), walking pace, or low hand grip strength with depression. Additionally, multivariable MR (MVMR) was performed to assess the dependence of each muscle trait in the causality and adjust the effect of body mass index (BMI). Supplementary backward MR analyses were performed to estimate the effect of depression on sarcopenia-related muscle traits.Univariable MR analyses demonstrated that there were causal associations of ALM (odds ratio [OR]: 0.94; 95% confidence interval [CI]: 0.88-0.99), walking pace (OR: 0.53; 95% CI: 0.32-0.88), and low hand grip strength (OR: 1.20; 95% CI: 1.05-1.38) with depression. MVMR analyses showed that ALM was the only trait that had a significant causal relationship with depression (OR: 0.91; 95% CI: 0.85-0.98) after accounting for the other two muscle traits. Moreover, the independent association of ALM with depression remained (OR: 0.92; 95% CI: 0.85-0.99) after being adjusted by BMI. The backward MR analyses showed no causal associations of depression with any sarcopenia-related muscle traits.Low muscle mass independently increases the risk of depression. This study determined the muscle-related risk factors of depression, which may help establish the causality between sarcopenia and depression and provide evidence-based recommendations for improving mental health in the elderly.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
4秒前
4秒前
8秒前
Zhang发布了新的文献求助10
8秒前
narcissuxxs发布了新的文献求助10
9秒前
LiMuzi发布了新的文献求助10
10秒前
ye_hang发布了新的文献求助80
11秒前
所所应助毛毛采纳,获得10
11秒前
gjww应助科研通管家采纳,获得10
11秒前
脑洞疼应助科研通管家采纳,获得10
11秒前
Orange应助科研通管家采纳,获得10
11秒前
科研通AI2S应助科研通管家采纳,获得10
11秒前
12秒前
12秒前
今后应助narcissuxxs采纳,获得10
12秒前
幽默的安雁完成签到 ,获得积分10
13秒前
14秒前
小老板完成签到,获得积分20
17秒前
烙饼发布了新的文献求助10
19秒前
21秒前
25秒前
毛毛发布了新的文献求助10
26秒前
35秒前
botanist完成签到 ,获得积分10
36秒前
123完成签到 ,获得积分10
36秒前
Gcole完成签到,获得积分10
37秒前
稳重向南完成签到,获得积分10
39秒前
40秒前
Zhang发布了新的文献求助10
41秒前
43秒前
dyfsj发布了新的文献求助10
46秒前
cleff发布了新的文献求助10
46秒前
46秒前
NexusExplorer应助Zhang采纳,获得10
48秒前
49秒前
51秒前
51秒前
chenchen完成签到,获得积分20
52秒前
54秒前
高分求助中
Manual of Clinical Microbiology, 4 Volume Set (ASM Books) 13th Edition 1000
Edestus (Chondrichthyes, Elasmobranchii) from the Upper Carboniferous of Xinjiang, China 500
Chinese-English Translation Lexicon Version 3.0 500
Electronic Structure Calculations and Structure-Property Relationships on Aromatic Nitro Compounds 500
マンネンタケ科植物由来メロテルペノイド類の網羅的全合成/Collective Synthesis of Meroterpenoids Derived from Ganoderma Family 500
Two-sample Mendelian randomization analysis reveals causal relationships between blood lipids and venous thromboembolism 400
薩提亞模式團體方案對青年情侶輔導效果之研究 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2380796
求助须知:如何正确求助?哪些是违规求助? 2088072
关于积分的说明 5243623
捐赠科研通 1815094
什么是DOI,文献DOI怎么找? 905666
版权声明 558810
科研通“疑难数据库(出版商)”最低求助积分说明 483581