化学
异构化
铜
芳基
亲核细胞
催化作用
光化学
表面改性
立体选择性
组合化学
有机化学
烷基
物理化学
作者
Shengkun Guo,Xiaoyu Shen,Xiaoyun Chen,Huaguang Yu,Ying Han,Chao‐Guo Yan,Yao‐Cheng Shi,Hong Hou,Shaoqun Zhu
标识
DOI:10.1021/acs.joc.3c01181
摘要
Described herein is a photoinduced copper-catalyzed 1,2-difunctionalization of 1,3-dienes. The selenium atom radical was generated by the visible light irradiation of diselenides, triggering radical addition with 1,3-dienes to form allyl radical intermediate. Subsequent rapid Z/E isomerization allowed for thermodynamically favorable intermediate formation and enabled copper catalyzed stereoselective functionalization with various nucleophiles.
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