对映选择合成
催化作用
过渡金属
轴手性
轴对称性
环加成
阿托品
手性(物理)
化学
有机催化
组合化学
计算化学
有机化学
手征对称破缺
对称性破坏
物理
量子力学
Nambu–Jona Lasinio模型
作者
Pu-Fan Qian,Tao Zhou,Bing‐Feng Shi
摘要
Axially chiral styrenes, a type of atropisomer analogous to biaryls, have attracted great interest because of their unique presence in natural products and asymmetric catalysis. Since 2016, a number of methodologies have been developed for the atroposelective construction of these chiral skeletons, involving both transition metal catalysis and organocatalysis. In this feature article, we aim to provide a comprehensive understanding of recent advances in the asymmetric synthesis of axially chiral styrenes catalyzed by transition metals, integrating scattered work with different catalytic systems together. This feature article is cataloged into five sections according to the strategies, including asymmetric coupling, enantioselective C-H activation, central-to-axial chirality transfer, asymmetric alkyne functionalization, and atroposelective [2+2+2] cycloaddition.
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