Photoredox‐Catalyzed Three‐Component Difluoroalkylation of Quinoxalin‐2(1H)‐ones with Unactivated Vinylarenes and [Ph3PCF2H]+Br−

Abstract An efficient synthesis of a variety of 3‐difluoroalkyl quinoxalin‐2(1 H )‐ones via a photoredox‐catalyzed three‐component reaction between quinoxalin‐2(1 H )‐ones, vinylarenes, with inexpensive and easily accessible difluoromethyltriphenyl phosphonium bromide salt as the difluoromethylated reagent is described. This protocol shows excellent reactivity, providing a wide range of difluoroalkyl‐substituted quinoxalin‐2(1 H )‐ones in moderate to excellent yields under mild conditions. A difluoroalkyl radical intermediate was involved in this three‐component transformation.