化学
试剂
鏻盐
溴化物
催化作用
钋
反应性(心理学)
组合化学
组分(热力学)
盐(化学)
药物化学
有机化学
医学
物理
替代医学
病理
热力学
作者
Yuan Xu,Hongzhao Qu,Jinwei Yuan,Ning Guo,Liangru Yang,Yanli Yin,Lingbo Qu,Jian Mao
标识
DOI:10.1002/ajoc.202300405
摘要
Abstract An efficient synthesis of a variety of 3‐difluoroalkyl quinoxalin‐2(1 H )‐ones via a photoredox‐catalyzed three‐component reaction between quinoxalin‐2(1 H )‐ones, vinylarenes, with inexpensive and easily accessible difluoromethyltriphenyl phosphonium bromide salt as the difluoromethylated reagent is described. This protocol shows excellent reactivity, providing a wide range of difluoroalkyl‐substituted quinoxalin‐2(1 H )‐ones in moderate to excellent yields under mild conditions. A difluoroalkyl radical intermediate was involved in this three‐component transformation.
科研通智能强力驱动
Strongly Powered by AbleSci AI