Armoring a liposome-integrated tissue factor with sacrificial CaCO3 to form potent self-propelled hemostats

脂质体 止血 材料科学 生物相容性 组织因子 纳米技术 凝结 生物医学工程 外科 医学 冶金 精神科
作者
ChengKun Liu,Zhuang Shi,Jianming Zhu,Chang Liu,Xiaodan Liu,Naseer Ullah Khan,Shihai Liu,Xiaojuan Wang,Xiaoqiang Wang,Fang Huang
出处
期刊:Journal of Materials Chemistry B [The Royal Society of Chemistry]
卷期号:11 (12): 2778-2788 被引量:5
标识
DOI:10.1039/d2tb02140d
摘要

The development of hemostatic materials suitable for diverse emergency scenarios is of paramount significance, and there is growing interest in wound-site delivery of hemostasis-enhancing agents that can leverage the body's inherent mechanisms. Herein we report the design and performance of a biomimetic nanoparticle system enclosing tissue factor (TF), the most potent known blood coagulation trigger, which was reconstituted into liposomes and shielded by the liposome-templated CaCO3 mineralization. The mineral coatings, which mainly comprised water-soluble amorphous and vateritic phases, synergized with the lipidated TF to improve blood coagulation in vitro. These coatings served as sacrificial masks capable of releasing Ca2+ coagulation factors or propelling the TF-liposomes via acid-aided generation of CO2 bubbles while endowing them with high thermostability under dry conditions. In comparison to commercially available hemostatic particles, CaCO3 mineralized TF-liposomes yielded significantly shorter hemostasis times and less blood loss in vivo. When mixed with organic acids, the CO2-generating formulation further improved hemostasis by delivering TF-liposomes deep into actively bleeding wounds with good biocompatibility, as observed in a rat hepatic injury model. Therefore, the designed composite mimicry of coagulatory components exhibited strong hemostatic efficacy, which in combination with the propulsion mechanism would serve as a versatile approach to treating a variety of severe hemorrhages.
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