A de novo strategy for the development of a Zn II –organic framework based luminescent “switch-on” assay for size-exclusive sensitization of the oxidised form of glutathione (GSSG) over the reduced form (GSH): insights into the sensing mechanism through DFT

The ratio of GSSG to GSH plays a key role as a biomarker for monitoring cellular health thus fuelling extensive ground-breaking research towards the development of robust sensory receptors for continuous monitoring of glutathione concentration.