化学
立体中心
单萜
立体化学
差向异构体
吲哚试验
生物化学
对映选择合成
催化作用
作者
Carsten Schotte,Yindi Jiang,Dagny Grzech,Thu-Thuy T. Dang,Larissa C. Laforest,Francisco León,Marco Mottinelli,Satya Swathi Nadakuduti,Christopher R. McCurdy,Sarah E. O’Connor
摘要
Mitragyna speciosa ("kratom") is used as a natural remedy for pain and management of opioid dependence. The pharmacological properties of kratom have been linked to a complex mixture of monoterpene indole alkaloids, most notably mitragynine. Here, we report the central biosynthetic steps responsible for the scaffold formation of mitragynine and related corynanthe-type alkaloids. We illuminate the mechanistic basis by which the key stereogenic center of this scaffold is formed. These discoveries were leveraged for the enzymatic production of mitragynine, the C-20 epimer speciogynine, and fluorinated analogues.
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