Techniques to Fabricate Electrospun Nanofibers for Controlled Release of Drugs and Biomolecules

Electrospinning is a nanotechnology-based platform with great potential in tissue engineering and related biomedical applications. The high surface-to-volume ratio of nanofibers makes them ideal candidates for the controlled delivery of drugs and biomolecules. The successful loading of multiple drugs and their controlled and sustained release at the targeted sites renders them suitable for guided tissue engineering applications. This chapter provides an overview of the electrospinning process and its advanced modification for successful encapsulation of drugs, biomolecules, and gene products to develop nanofiber-based therapeutic systems for biomedical applications, particularly focusing on the repair and regeneration of tissues. The gaps in the field and opportunities for future research are highlighted.