卡宾
催化作用
化学
偶联反应
光化学
功能群
烷氧基
联轴节(管道)
组合化学
基质(水族馆)
金属
药物化学
高分子化学
有机化学
材料科学
烷基
海洋学
地质学
冶金
聚合物
作者
Zhonghua Lu,Xueying Guo,Yingchao Li,Yichen Wu,Xiao‐Song Xue,Peng Wang
标识
DOI:10.1002/anie.202216373
摘要
The transition metal-catalyzed cross-coupling reaction with Fischer metal carbene intermediates bearing an electron-rich alkoxyl or siloxyl group remains a big challenge due to the lack of readily available corresponding carbene precursors. Herein, we report the coupling of alkynes with the Fischer-type copper carbene species bearing a α-siloxyl group, which could be in situ generated from acylsilanes catalytically under photoirradiation and redox-neutral conditions. The side-arm modified bisoxazoline (SaBox) ligands prove to be crucial for this coupling reaction, which provides the corresponding alkynyl alcohol in high yields with remarkable heterocycle tolerance and broad substrate scope.
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