213P Type-1 diabetes restricts melanoma growth by reprogramming intra-tumoral T cell metabolism

Epidemiological studies from Bendix et al. (2016) with 5 countries and 9000 type-I diabetes mellitus (T1DM) patients with cancers showed reduced risk in melanoma, breast and prostate cancer and increased risk of oesophagus, stomach, colon and liver cancer, suggested differential consequences of T1DM with cancers of different etiopathology. However, prospective studies to decipher the possible mechanism are not well documented. In both T1DM and cancer, CD8+ T cells plays crucial role and faces functional as well as metabolic alterations.