Identification and Targeting of POLQ -Associated Hereditary Colorectal Cancer

This study identifies POLQ as a pathogenic gene in hereditary colorectal cancer, unveiling a novel POLQ-type colorectal cancer driven by TMEJ hyperactivation. Screening for POLQ mutations in patients with hereditary adenomas or early-onset colorectal cancer would benefit early diagnosis and personalized therapy for POLQ-associated colorectal cancer; however, further clinical validation is warranted.